Variation in Nerve Fiber Strain in Brain Tissue Subjected to Uniaxial Stretch

The most frequent type of closed head injury involved in vehicular accidents is diffuse axonal injury (DAI), which is characterized by structural and functional damage of nerve fibers in the white matter that may be caused by their overstretch. Because nerve fibers in the white matter have an undulated network-like structure embedded in the neuroglia and extracellular matrix, and are expected to be much stiffer than other components, the strain in the nerve fiber is not necessarily equal to that in the white matter. In this study, the authors have measured strain of the nerve fibers running in various directions in porcine brain tissue subjected to uniaxial stretch and compared them with global strain (tissue strain). The nerve fiber strain had a close correlation with their direction, and was smaller than surrounding global strain. Consideration of neural fiber alignment in the white matter is important in studying the mechanical aspects of pathogenesis in DAI.


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  • Accession Number: 01102868
  • Record Type: Publication
  • ISBN: 9780768019742
  • Files: TRIS
  • Created Date: Jun 16 2008 11:44AM