A New Model of Traumatic Axonal Injury to Determine the Effects of Strain and Displacement Rates

Motor vehicle accidents are the leading cause of traumatic brain injury (TBI). In many cases of TBI widespread disruption of the axons occurs through a process known as diffuse axonal injury or traumatic axonal injury (TAI). In this study an in vivo TAI model was developed using spinal nerve roots of adult rats. Functional and structural responses of axons to various strains and displacement rates were determined with this model. Results from this study indicate that the severity of both functional and structural injury increases with increases in strain and displacement rate.


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  • Accession Number: 01046260
  • Record Type: Publication
  • ISBN: 139780768018295
  • Files: TRIS
  • Created Date: Apr 19 2007 1:29PM