ELEVATED RISK FOR MALE BREAST CANCER AFTER OCCUPATIONAL EXPOSURE TO GASOLINE AND VEHICULAR COMBUSTION PRODUCTS

Automotive gasoline contains benzene, 1,3-butadiene, 1,2-dibromoethane, and 1,2-dichloroethane, and the combustion products include certain polycyclic aromatic hydrocarbons, all of which have shown mammary gland carcinogenicity in long-term bioassays. The aim of this paper is to investigate whether men occupationally exposed to gasoline and its combustion products have an elevated risk of breast cancer. A national register-based case control study on male breast cancer morbidity was set-up among members of a pension fund, compulsory for all employees. Employment histories were reconstructed for each of 230 cases and 12,880 control subjects based on computerized records. The odds ratios, adjusted for SES, were estimated by conditional logistic regression analysis. When a lag time of at least 10 years was included, the odds ratio for breast cancer among men with over 3 months of employment in trades with potential exposure to gasoline and combustion products was 2.5 (95% CI: 1.3-4.5). Among men younger than 40 years at the time of first employment, the odds ratio was 5.4 (2.4-11.9). This study supports the hypothesis that occupational exposure to gas vapors and combustion products may play a role in the causation of male breast cancer. This hypothesis warrants further evaluation, particularly in women.

  • Availability:
  • Corporate Authors:

    John Wiley & Sons, Incorporated

    111 River Street
    Hoboken, NJ  United States  07030-6000
  • Authors:
    • HANSEN, J
  • Publication Date: 2000-4

Language

  • English

Media Info

  • Features: References;
  • Pagination: p. 349-352
  • Serial:

Subject/Index Terms

Filing Info

  • Accession Number: 00800461
  • Record Type: Publication
  • Files: TRIS
  • Created Date: Oct 26 2000 12:00AM