THE EFFECTS OF FOUR ANTI-HYPERTENSIVE AGENTS UPON THE PERFORMANCE OF NORMAL SUBJECTS ON DRIVING RELATED SKILLS

The present study was designed to determine the effects of four anti-hypertensive agents given over a period of seven days to normal subjects on a number of driving-related skills. Sixty healthy male volunteers were randomly assigned to one of six treatment groups on a double-blind basis: (1) atenolol - 50 mg t.d.s, (2) methyl dopa - 250 mg t.d.s, (3) propranolol - 40 mg t.d.s, (4) reserpine - 0.2 mg t.d.s, (5) placebo, and (6) control - no tablets. Tests were carried out (1) before treatment, (2) two hours after the first dose, (3) on the third day after seven doses, and (4) on the seventh day after 21 doses. The driving tasks consisted of (1) weaving around a series of bollards whilst simultaneously responding to an auditory logic task and (2) a gap acceptance task. Kinetic visual acuity - an important driving-related ability - was also measured. The data were analysed using an analysis of covariance repeated measures design with the pre-test score as the covariate. All the four drugs showed some degree of impairment on at least one of the tasks. Methyl dopa tended to show the most consistent impairment. Both atenolol and propranolol also showed improvement on some of the paced tasks, possibly reflecting the anxiolytic effects of these drugs.

  • Corporate Authors:

    Birmingham University, England

    P.O. Box 363
    Birmingham B15 2TT, Warwickshire,   England 
  • Authors:
    • CLAYTON, A B
    • Harvey, P G
    • BETTS, T A
  • Publication Date: 1976-4

Language

  • English

Media Info

  • Features: Figures; References;
  • Pagination: 19 p.

Subject/Index Terms

Filing Info

  • Accession Number: 00168169
  • Record Type: Publication
  • Source Agency: Transport and Road Research Laboratory (TRRL)
  • Report/Paper Numbers: Departmental Rpt. 48Monograph
  • Files: ITRD, TRIS
  • Created Date: Jun 14 1978 12:00AM