PREDICTION OF EXPERIMENTAL DIFFUSE AXONAL INJURY SEVERITY USING MACROSCOPIC HEAD MOTION PARAMETERS

The interrelationship between impulsive head loading parameters and either the presence and/or severity of diffuse axonal damage has not been fully developed. In this investigation, an experimental model of diffuse axonal injury is used to explore the relationship between intracranial deformations and axonal injury patterns. Surrogate models of the miniature pig skull-brain structure were tested to develop emperical relationships for the regional brain tissue distortion occurring in response to an impulsive head rotation. The study represents a first approach towards merging biomechanical data with neuroanatomic information to relate the distribution and severity of axonal injury with specific macroscopic head motion parameters.For the covering abstract of the conference see IRRD 873507.

• Corporate Authors:

  ASSOCIATION FOR THE ADVANCEMENT OF AUTOMOTIVE MEDICINE (AAAM)

  2350 EAST DEVON AVENUE, SUITE 205
  DES PLAINES,   United States  60018
• Authors:
  • MEANEY, D F
  • SMITH, D S
  • SHREIBER, D I
  • RAHDERT, D A
  • BOGEN, D K
  • ROSS, D T
  • MCINTOSH, T K
  • Gennarelli, T A
• Conference:
  • PROCEEDINGS OF THE THIRTY-EIGHTH ANNUAL CONFERENCE OF THE ASSOCIATION FOR THE ADVANCEMENT OF AUTOMOTIVE MEDICINE, SEPTEMBER 21-23, 1994, LYON, FRANCE
• Publication Date: 1994

Language

• English

Media Info

• Features: References;
• Pagination: p. 345-58

Subject/Index Terms

• TRT Terms: Animals; Biophysics; Brain; Conferences; Crash severity; Crash tests; Forecasting; Head; Injuries; Injury severity; Loss and damage; Rotation; Skull
• Geographic Terms: United States
• ITRD Terms: 2459: Animal; 2060: Biomechanics; 2030: Brain; 8525: Conference; 1614: Damage; 132: Forecast; 1648: Impact test (crash); 2163: Injury; 6406: Rotation; 1623: Severity (accid, injury); 2021: Skull; 8122: USA
• Subject Areas: Research; Safety and Human Factors;

Filing Info

• Accession Number: 00714323
• Record Type: Publication
• Source Agency: Institute for Road Safety Research, SWOV
• Files: ITRD
• Created Date: Dec 27 1995 12:00AM