THE PHARMACOKINETIC COMPONET OF DRUG EFFECTS ON DRIVING SKILLS

This paper discusses the extent and source of inter-individual variations in metabolic fate of drugs other than alcohol upon driving skills. Serum concentrations are better predictors of therapeutic effect of toxicity than dose for many drugs. The evidence is best for drugs with easily measurable and points of clinical efficacy, and worst with psychotherapeutic agents. Paradoxically, serum concentration measurements will be of greatest use eventually where direct measurements of therapeutic effect or toxicity is most difficult. The design of future studies of drug effects on driving skills should be based on a greater awareness of the metabolic fate and pharmacologic actions of the experimental drugs. (MW)

Media Info

  • Features: Figures; References; Tables;
  • Pagination: p. 271-293

Subject/Index Terms

Filing Info

  • Accession Number: 00132143
  • Record Type: Publication
  • Source Agency: National Safety Council Safety Research Info Serv
  • Report/Paper Numbers: Proceeding
  • Files: TRIS, USDOT
  • Created Date: Dec 8 1977 12:00AM