ANTIHISTAMINE EFFECTS ON MOTOR SKILLS AND VIGILANCE

This investigation was to determine the degree and the manner in which the performance abilities of 12 female subjects were affected, by a nonprescription antihistamine cold and hay fever drug compound, in two simulated industrial work tasks--one requiring vigilance and the other requiring sensory-motor function. For both tasks, performance was measured before ingestion, 0.5 hour after ingestion, 2.5 hours after, and 4.5 hours after. Responses to three key lights, each repeated twice in a 120-light sequence, were measured; the light sequence was patterned to include each type of biplanar motion and its reciprocal. Six trial runs of each task were recorded in each time period. Vigilance task independent variables were response time, late responses, missed responses, false responses, and frequency of purposeful eye movements. Motor Skills task dependent variables were interval time, total time task performance, pathlength, velocity peaks. In the vigilence task, subjects under antihistamine had small differences in response time for key lights detected. The investigation proved that missed responses would be statistically significant. False responses did not achieve statistical significance, nor did purposeful eye movements. No dependent variables of the motor skills task achieved statistical significance at the 0.05 probability level. It was concluded that for occupational safety and health, active bodily motion should be incorporated into inspection and monitoring tasks. In the vigilance task the horizontal area is a poorer choice for the location of dials or of a product to be inspected. In the motor skills task the side position of the workplace should be restricted to storage of the least-used components and tools. The combined negative effects of time period and antihistamine were greater 0.5 hour after ingestion than 2.5 hours after ingestion. /MW/

  • Supplemental Notes:
    • This research was sponsored by the National Institute for Occupational Safety and Health.
  • Corporate Authors:

    New York University, New York

    New York, NY  United States  10003
  • Authors:
    • Tichauer, E R
    • Harrison, L B
  • Publication Date: 1975-1

Media Info

  • Features: Figures; References; Tables;
  • Pagination: 119 p.

Subject/Index Terms

Filing Info

  • Accession Number: 00098929
  • Record Type: Publication
  • Source Agency: National Safety Council Safety Research Info Serv
  • Report/Paper Numbers: Final Rpt.
  • Contract Numbers: 1 RO1 OH 00432-01
  • Files: TRIS
  • Created Date: Sep 30 1975 12:00AM