GRADED NEUROPSYCHOLOGICAL IMPAIRMENT AND ELEVATED GAMMA-GLUTAMYL TRANSFERASE IN CHRONIC ALCOHOLIC MEN

The study hypothesizes that distinct biochemical and metabolic disturbances associated with liver injury may be related to specific cognitive changes in alcoholics. In 132 alcoholic men admitted to an alcohol treatment program, increases in gamma glutamyl transferase (GGT) values were correlated with impairment in several measures of visuoperceptual and visuoconceptual functioning. The association between plasma levels of GGT and neuropsychological performance was independent of the relative contribution of other laboratory measures of liver injury and of alcohol consumption histories. These observations support the hypothesis that elevated levels of GGT are distinctly associated with neuropsychological deficits and suggest that possible mechanisms beyond severe hepatic dysfunction and alcohol consumption underlie cognitive deficits in alcoholics.

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/issn/01456008
• Corporate Authors:

  Marcel Dekker, Incorporated

  270 Madison Avenue
  New York, NY  United States  10016
• Authors:
  • Irxin, M
  • Smith, T L
  • Butters, N
  • BROWN, S
  • Baird, S
  • Grant, I
  • Schuckit, M A
• Publication Date: 1989

Media Info

• Pagination: p. 99-103
• Serial:
  • Alcoholism: Clinical and Experimental Research
  • Volume: 13
  • Issue Number: 1
  • Publisher: Blackwell Publishing
  • ISSN: 0145-6008
  • EISSN: 1530-0277
  • Serial URL: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1530-0277

Subject/Index Terms

• TRT Terms: Alcoholism; Biochemistry; Cognitive impairment; Drunk drivers; Drunk driving; Metabolism; Neurology; Persons with disabilities; Psychological aspects
• Subject Areas: Highways; Safety and Human Factors; Society; I83: Accidents and the Human Factor;

Filing Info

• Accession Number: 00493880
• Record Type: Publication
• Files: TRIS
• Created Date: Apr 30 1990 12:00AM