THE EFFECTS OF ALCOHOL ON PSYCHOLOGICAL FUNCTIONS IN NORMAL VOLUNTEERS AFTER 8 DAYS' TREATMENT WITH PIPEQUALINE (PK 8165), DIAZEPAN OR PLACEBO

The effects of daily administration for 8 days of 50 mg pipequaline, 10 mg diazepam and placebo were assessed in a double-blind cross-over study with 12 healthy volunteers. this study also tested for an interaction between the drugs and alcohol on the eighth day. Subjective ratings, psychomotor and memory performance were evaluated. Diazepam produced the typical pattern of changes, namely impairments in psychomotor performance and reductions in the retention of newly memorized information. In contrast, the effects of pipequaline were relatively minor. In general, neither drug potentiated the effects of alcohol on performance, only isolated instances of non-additive interactions occurring. Subjective reports revealed that whereas both ative drugs increased feelings of calmness, this result was accomplished by pipequaline with considerably less drowsiness, no euphoria and an absence of adverse side effects of diazepam.

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/issn/00316970
• Corporate Authors:

  Springer Verlag

  175 5th Avenue
  New York, NY  United States  10010
• Authors:
  • Eves, F F
  • Lader, M H
• Publication Date: 1989

Media Info

• Pagination: p. 47-52
• Serial:
  • European Journal of Clinical Pharmacology
  • Volume: 36
  • Issue Number: 1
  • Publisher: Springer Verlag
  • ISSN: 0031-6970

Subject/Index Terms

• TRT Terms: Alcoholic beverages; Drugs; Motor skills; Placebos; Psychological aspects
• Uncontrolled Terms: Psychomotor performance
• Subject Areas: Highways; Safety and Human Factors; I83: Accidents and the Human Factor;

Filing Info

• Accession Number: 00491088
• Record Type: Publication
• Files: TRIS
• Created Date: Feb 28 1990 12:00AM