Traffic-related air pollution, chronic stress, and changes in exhaled nitric oxide and lung function among a panel of children with asthma living in an underresourced community
The authors examined associations between short-term exposure to traffic-related air pollutants (TRAP) and airway inflammation and lung function in children with asthma, and whether these associations are modified by chronic psychological stress. Residents of underresourced port-adjacent communities in New Jersey were concerned about the cumulative impacts of exposure to TRAP, particularly diesel-engine truck emissions, and stress on exacerbation of asthma among children. Children with asthma aged 9–14 (n = 35) were recruited from non-smoking households. The authors measured each participant's (1) continuous personal exposure to black carbon (BC, a surrogate of TRAP) at 1-min intervals, (2) 24-h integrated personal exposure to nitrogen dioxide (NO₂), (3) daily fractional exhaled nitric oxide (FeNO), and (4) lung function for up to 30 consecutive days. Personal BC was recorded by micro-aethalometers. They measured daily FeNO using the NIOX MINO, forced expiratory volume in one second (FEV1), and forced vital capacity (FVC) using Easy One Frontline spirometers. Chronic stress was measured with the UCLA Life Stress Interview for Children. The association was examined using linear mixed-effect models. In the fully adjusted model, an interquartile range (IQR) increase in BC at lag 0–6 h before the FeNO measurement was associated with 8 % (95 % CI: 3 % - 12 %) increase in FeNO, whereas an IQR increase in BC at lag 7–12 h and lag 0–24 h were associated with 6 % (95 % CI: 2 % - 11 %) and 7 % (2 % - 12 %) FeNO increases, respectively. There were no significant lung function changes per IQR increase in BC. No interactions were observed between chronic stress and BC on FeNO. Chronic stress was negatively associated with individual average FeNO levels. The findings suggest that higher levels of BC exposure within the prior 24 h increased airway inflammation levels in children with asthma, with the strongest effect observed within the first 6 h.
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Availability:
- Find a library where document is available. Order URL: http://worldcat.org/issn/00489697
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Supplemental Notes:
- © 2023 Published by Elsevier B.V. Abstract reprinted with permission of Elsevier.
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Authors:
- Ji, N
- Baptista, A
- Yu, C H
- Cepeda, C
- Green, F
- Greenberg, M
- Colon Mincey, I
- Ohman-Strickland, P
- Fiedler, N
- Kipen, H M
- Laumbach, R J
- Publication Date: 2024-2-20
Language
- English
Media Info
- Media Type: Web
- Features: References;
- Pagination: 168984
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Serial:
- Science of the Total Environment
- Volume: 912
- Issue Number: 0
- Publisher: Elsevier
- ISSN: 0048-9697
- Serial URL: http://www.sciencedirect.com/science/journal/00489697
Subject/Index Terms
- TRT Terms: Air pollution; Children; Highway traffic; Respiratory system; Stress (Psychology); Underserved communities
- Geographic Terms: New Jersey
- Subject Areas: Environment; Highways; Safety and Human Factors; Society;
Filing Info
- Accession Number: 01902700
- Record Type: Publication
- Files: TRIS
- Created Date: Dec 19 2023 5:08PM