Two doses of ethyl alcohol were administered to 48 young male subjects (24 brother-pairs), and placebo doses were administered to 5 brother-pairs (controls). Dose 1 amount was calculated to result in a peak blood alcohol content (BAC) of 100 mg/dl; Dose 2 was given when BAC had fallen to one-half the peak BAC resulting from Dose 1, in an attempt to raise BAC back to 100 mg/dl. Prior to alcohol dosage, baseline measurements were made on a number of behavioral tests. Behavioral performances during metabolism of Doses 1 and 2 were compared to baseline performance. Sensitivity to ethanol was indicated by performance decrements on nearly all tests after ethanol dosing. Acute behavioral tolerance to ethanol (ABTE) was indicated for some tests by improved performance after Dose 2 compared to performance at a time after Dose 1 when BACs were about equivalent. A preliminary search for possible genetic components of sensitivity and ABTE was undertaken by comparing the scores of the brothers.

  • Corporate Authors:

    University of Colorado, Boulder

    Institute for Behavioral Genetics and Alcohol Research Center
    Boulder, CO  United States  80309
  • Authors:
    • Wilson, J R
    • Erwin, V G
    • McClearn, G E
    • Plomin, R
    • Johnson, R C
    • Ahern, F M
    • Cole, R E
  • Publication Date: 1983

Media Info

  • Features: Figures; References; Tables;
  • Pagination: 35 p.

Subject/Index Terms

Filing Info

  • Accession Number: 00391121
  • Record Type: Publication
  • Source Agency: National Highway Traffic Safety Administration
  • Report/Paper Numbers: HS-037 017
  • Contract Numbers: AA-03527
  • Files: HSL, USDOT
  • Created Date: Nov 30 1984 12:00AM