No effect on driving capability can be expected from orally taken digestive agents. If these drugs contain an additional spasmolytic agent with anticholinergic action, then there is the danger of visual impairment. The effect on accommodation and sensitivity to blinding of deflazenum, a synthetic anticholinergic agent, is compared with atropin under different dosages. 30 test persons varying in age from 19 to 30 yr were randomised and classified into three medication groups who were given the following medication under double blind conditions for a period of 8 days: 3 X 2 dragees deflazenum or 3 x 0,5 mg atropinsulfate and 3 X 1 placebo or 3 x 2 placebos daily. The following parameters were measured in the evening of the first day and in the evening of the 8th day: sharpness of close by and long distance vision; stereoscopic vision; and readaptation speed after blinding and vision acuity during blinding. Reaction and alertness performance were tested by means of traffic psychological methods with emphasis on optical techniques. The results were tested for significance by means of the h-test of Kruskal and Wallis, the Pratt-test and the test of Freeman and Halton. On the 8th day there was no change in accommodation ability in the deflazenum group, whereas a significant accommodation weakness had occurred in the atropin group. In both verum groups, sensitivity to blinding was increased as compared with the placebo groups. A reduction in reaction and alertness could not be established. Sensitivity to blinding was felt more acutely in the atropin group than in the deflazenum group. In 2 out of 10 cases it was necessary to replace the reference drug by placebo in spite of the low dosage used. (Author/TRRL)

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  • Corporate Authors:


    Lenzhalde 3, P.O. Box 2945
    7000 Stuttgart 1,   Germany 
  • Authors:
    • MOSER, L
    • Lind, P V
  • Publication Date: 1980


  • German

Media Info

  • Pagination: p. 1795-98
  • Serial:

Subject/Index Terms

Filing Info

  • Accession Number: 00385989
  • Record Type: Publication
  • Source Agency: Transport Research Laboratory
  • Files: ITRD, TRIS
  • Created Date: Jul 30 1984 12:00AM