CATALYTICALLY AND NONCATALYTICALLY TREATED AUTOMOBILE EXHAUST: BIOLOGICAL EFFECTS IN RATS

Chronic exposure to catalytically treated or noncatalytically treated automobile exhaust significantly depressed the spontaneous locomotor activity (SLA) of rats. Exposure to H2SO4 alone or CO at comparable levels did not alter the SLA. Exposure to noncatalytically treated exhaust resulted in significant reductions in growth rate and food and water intake. However, these effects were not evident in the exposure to catalytically treated exhaust or in the control H2SO4 and CO exposures. Blood acid-base analyses indicated that exposure to either catalytically treated exhaust or H2SO4 elicits a metabolic alkalosis, while exposure to CO alone results in a metabolic acidosis. All acid-base parameters were within the normal range several weeks after the termination of exposure.

• Corporate Authors:

  University of Cincinnati

  Department of Environmental Health
  Cincinnati, OH  United States  45221

  Environmental Protection Agency

  Health Effects Research Laboratory
  Research Triangle Pk, NC  United States  27711
• Authors:
  • Cooper, G P
  • Lewkowski, J P
  • Hastings, L
  • Malanchuk, M
• Publication Date: 1981-6

Media Info

• Pagination: 14 p.

Subject/Index Terms

• TRT Terms: Alternatives analysis; Animals; Automobiles; Blood analysis; Carbon monoxide; Catalysis; Crash exposure; Exhaust gases; Laboratory animals; Metabolism; Physiological aspects; Rats; Reprints; Sulfuric acid; Toxicology; Urban growth
• Uncontrolled Terms: Exposure
• Old TRIS Terms: Blood chemical analysis; Toxicological tests
• Subject Areas: Highways; Safety and Human Factors; Vehicles and Equipment;

Filing Info

• Accession Number: 00344645
• Record Type: Publication
• Source Agency: National Technical Information Service
• Report/Paper Numbers: EPA/600/J-77-181
• Contract Numbers: EPA-68-03-0492
• Files: TRIS
• Created Date: Dec 22 1982 12:00AM