PULMONARY FUNCTION AND PATHOLOGY IN CATS EXPOSED 28 DAYS TO DIESEL EXHAUST

Young adult male cats were exposed 28 days, 20 hours per day, to a 1:14 dilution of diesel exhaust emissions. Following termination of exposure, the following pulmonary function measurements were carried out: lung volumes, maximum expiratory flow rates (MEF), MEF at 50%, 25% and 10% of vital capacity (VC): forced expiratory volume (FEV) after 0.2, 0.3 and 0.4 seconds, dynamic compliance, resistance and helium washout at 25, 50, 75 and 100 breaths per minute. The only significant functional change was a decrease in MEF at 10% of VC (P= .02). The lungs of the exposed cats appeared charcoal grey with frequent focal black spots visible for the pleural surface. Pathologic changes in the exposed cats included a predominantly peribronchiolar localization of black-pigmented macrophages within the alveoli producing a focal pneumonitis or alveolitis. In general, evidence of serious lung damage was not observed following the 28-day exposure period.

• Corporate Authors:

  Environmental Protection Agency

  Health Effects Research Laboratory
  Research Triangle Pk, NC  United States  27711
• Authors:
  • Pepelko, W E
  • Mattox, J K
  • Yang, Y Y
  • Moore, W J
• Publication Date: 1980-11-10

Media Info

• Pagination: 11 p.

Subject/Index Terms

• TRT Terms: Animals; Cats; Concentration (Chemistry); Crash exposure; Diesel fuels; Diseases and medical conditions; Environmental impacts; Exhaust gases; Experiments; Health; Laboratory animals; Lungs; Pathology; Reprints; Respiratory system; Toxicology
• Uncontrolled Terms: Exposure
• Subject Areas: Environment; Highways; Safety and Human Factors; Vehicles and Equipment;

Filing Info

• Accession Number: 00343357
• Record Type: Publication
• Source Agency: National Technical Information Service
• Report/Paper Numbers: EPA-600/J-80-180
• Files: TRIS
• Created Date: Oct 28 1982 12:00AM