PRINCIPLES OF TOXICOLOGICAL INTERACTIONS ASSOCIATED WITH MULTIPLE CHEMICAL EXPOSURES

The U.S. Coast Guard has an interest in the safety of all personnel exposed to hazardous materials in or on transport vessels. Its attempts to evaluate many of these hazards have been hampered by the lack of data on personnel other than Coast Guard marine inspectors. These inspectors are required to enter cargo tanks, voids, and cofferdams as well as normally manned spaces on ships to ascertain the physical integrity of the hull, machinery, and equipment. Since they may spend some time each day inside cargo tanks, the inspectors are likely to be exposed to many chemicals and other stress factors in varying combinations and sequences. Exposure of maritime personnel to a single substance under carefully controlled conditions is generally unrealistic. Although exposure to multiple chemicals and stresses prevails in many industries and in many environments, the problems associated with toxicological interactions have often been ignored. This report is a first attempt to assess the added hazards, if any, to marine inspectors who are occupationally exposed to multiple chemicals. The identification of data required to develop a set of principles governing toxicological interactions has broad applications that extend beyond the safety and health of Coast Guard and other marine personnel. Development of such principles should facilitate the prediction of potential hazards associated with the exposure of maritime personnel to multiple cargo vapors.

  • Corporate Authors:

    National Academy of Sciences-Natl Research Council

    Board on Toxicology and Environmental Health Hazards
    Washington, DC  USA  20418
  • Publication Date: 1980

Media Info

  • Features: References;
  • Pagination: v.p.

Subject/Index Terms

Filing Info

  • Accession Number: 00330528
  • Record Type: Publication
  • Contract Numbers: DOT-CG-74248-A
  • Files: TRIS
  • Created Date: Apr 15 1981 12:00AM