The significance of medicines as one of the possible causes of road accidents has become clearer during recent years and has emphasized the need for the continuing testing of medicines in this respect. Amongst those medicines, which because of their widespread use and certain well known side-effects are of particular interest in this connection, are the beta-blockers. In a double-blind study the two beta-blockers propranolol and pindolol were given to 20 healthy subjects in order to investigate their effects upon drivers and driving behaviour. The driving tests were carried out in practice areas. In addition to investigating several psychophysiological parameters and psychomental efficiency (tested through subsidiary exercises), the driving behaviour of the subjects was checked by the use of special driving exercises. Besides the predictable effect of the beta-blockers upon the heart-circulation system, a significant change in the psychophysiological reaction values could be determined. The psychomotoric co-ordination and reaction capability was negatively influenced by the beta-blockers. Together with the sedative side-effects indicated by many subjects, these results may be interpreted in the sense of a general reduction in activity caused by taking the beta-blockers. The pharmacological mechanism of the effective components of propranolol and pindolol are discussed together with the significance in terms of traffic-medicine. (TRRL)

  • Corporate Authors:

    Federal Institute of Road Research, Germany

    Bruhlerstrasse 1, Postfach 510530
    D-5000 Cologne 51,   Germany 
  • Authors:
    • Braun, P
    • REKER, K
    • FRIEDEL, B
    • Kockelke, W
  • Publication Date: 1978-12


  • German

Media Info

  • Features: Figures; References; Tables;
  • Pagination: 125 p.

Subject/Index Terms

Filing Info

  • Accession Number: 00324645
  • Record Type: Publication
  • Source Agency: Bundesanstalt für Straßenwesen (BASt)
  • Report/Paper Numbers: Monograph
  • Files: ITRD, TRIS
  • Created Date: Aug 15 1981 12:00AM