AUTOMOTIVE EXHAUST AND MOUSE ACTIVITY: RELATIONSHIPS BETWEEN POLLUTANT CONCENTRATIONS AND DECREASES IN WHEEL RUNNING
Groups of male and female mice inhaled either clean air, 100 ppm carbon monoxide, or light-irradiated and nonirridiated automotive exhaust containing nominally 25, 50, 75, or 100 ppm carbon monoxide in three tests with exposure lasting from 4 to 7 days. Exhaust from a factory or lean-tuned engine in the first and third tests reversibly suppressed activity wheel running during exposure in mice of both sexes by as much as 78.3 and 83.1 percent respectively. Light-irradiated exhaust suppressed running more than nonirradiated exhaust. For the second test, when the engine was tuned to be low in pollutants other than carbon monoxide, exhaust did not suppress running. Exposure to carbon monoxide alone only slightly decreased running in male mice, but increased running in female mice.
Health Effects Research LaboratoryRes Triangle Park, NC United States
- Gage, M I
- Publication Date: 1979
- Pagination: 8 p.
- TRT Terms: Air pollution; Carbon monoxide; Concentration (Chemistry); Contaminants; Crash exposure; Exhaust gases; Experiments; Females; Laboratory animals; Males; Radiation hazards; Reprints; Respiratory system; Toxicity; Vehicle power plants
- Uncontrolled Terms: Activity; Experimental data; Exposure; Relationships
- Old TRIS Terms: Automobile engines; Mice; Radiation effects
- Subject Areas: Highways; Safety and Human Factors; Vehicles and Equipment;
- Accession Number: 00312861
- Record Type: Publication
- Source Agency: National Technical Information Service
- Report/Paper Numbers: EPA/600/J-79/043
- Files: TRIS
- Created Date: May 7 1980 12:00AM