Urinary metabolites of 1-nitropyrene in US-Mexico border residents who frequently cross the San Ysidro Port of Entry.
In spite of the fact that a community exposure hazard is presented by diesel exhaust, the means by which to measure internal exposure are deficient. Results from a community-based study that used t-nitropyrene (1-NP) and its urinary metabolites as markers of exposure to traffic-related diesel particulate matter (DPM) are reported here. Residents of Tijuana, Mexico who commute via walking to San Diego, California for school or work via the International San Ysidro Port of Entry (known as border commuters) were placed within feet of idling traffic. These residents were participants in the study. Residents of south San Diego who did not commute into Mexico comprised the comparison group (non-border commuters). From personal samples from participants, measurements were made of air concentration of 1-NP in fine particulate matter (PM₂.₅). Spot urine samples were analyzed for 1-NP urinary metabolites 8-hydroxy-1-nitropyrene (8-OHNP) and 8-hydroxy-N-acetyl-1-aminopyrene (8-OHNAAP). Border commuters had two- to three-times higher mean urinary concentrations for unadjusted and creatinine-adjusted 8-OHNP and 8-OHNAAP, compared with non-border commuters. Associated with personal exposure to 1-NP in the prior 24 hours were both urinary 8-OHNAAP and the sum of 8-OHNP and 8-OHNAAP. It is suggested by the results that recent exposure to DPM-derived 1-NP in community settings is reflected in 1-NP urinary metabolites, and this information can be utilized for exposure analysis.
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Availability:
- Find a library where document is available. Order URL: http://worldcat.org/issn/15590631
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Authors:
- Galaviz, Vanessa Eileen
- Quintana, Penelope Jane
- Yost, Michael George
- Sheppard, Lianne
- Paulsen, Michael Henry
- Camp, Janice Ellouise
- Simpson, Christopher David
- Publication Date: 2017
Language
- English
Media Info
- Media Type: Web
- Features: References;
- Pagination: pp 84-89
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Serial:
- Journal of Exposure Science & Environmental Epidemiology
- Volume: 27
- Issue Number: 1
- Publisher: Nature Publishing Group
- ISSN: 1559-0631
- Serial URL: https://www.nature.com/jes/
Subject/Index Terms
- TRT Terms: Border crossings; Commuters; Diesel engine exhaust gases; Engine idling; Health hazards; Measurement of specific phenomena; Particulates; Pedestrians; Ports of entry; Urine
- Identifier Terms: San Ysidro Port of Entry
- Uncontrolled Terms: Exposure (Pollutants); Metabolites
- Geographic Terms: Mexico; San Diego (California); Tijuana (Mexico)
- Subject Areas: Environment; Highways; Pedestrians and Bicyclists; Safety and Human Factors;
Filing Info
- Accession Number: 01661003
- Record Type: Publication
- Files: TRIS
- Created Date: Feb 22 2018 9:20AM