Residential Proximity to Major Roadways, Fine Particulate Matter, and Hepatic Steatosis: The Framingham Heart Study

Nonalcoholic fatty liver disease refers to the presence of hepatic steatosis among individuals in the absence of excessive alcohol use or other causes of secondary fat accumulation. In this study, the authors explore the relationship between residential ambient air pollution, proximity to major highways, and hepatic steatosis. Using participants from the Framingham Offspring Study and the Framingham Third Generation Cohort, they measure liver attenuation via computed tomography and calculate liver-to-phantom ratio (LPR) to identify levels of liver fat. Differences in continuous LPR are estimated using linear regression models. The results show higher prevalence of hepatic steatosis among participants who live closer to a major roadway; however, the measured concentration of particulate matter is not found to be associated with LPR or hepatic steatosis.

Record URL:
Availability:
- Find a library where document is available. Order URL: http://worldcat.org/issn/00029262
Authors:
- Li, Wenyuan
- Dorans, Kirsten S
- Wilker, Elissa H
- Rice, Mary B
- Long, Michelle T
- Schwartz, Joel
- Coull, Brent A
- Koutrakis, Petros
- Gold, Diane R
- Fox, Caroline S
- Mittleman, Murray A
Publication Date: 2017

Language

English

Media Info

Media Type: Digital/other
Features: Figures; References; Tables;
Pagination: pp 857-865
Serial:
- American Journal of Epidemiology
- Volume: 186
- Issue Number: 7
- Publisher: Johns Hopkins University, Baltimore
- ISSN: 0002-9262
- Serial URL: http://aje.oxfordjournals.org/

Subject/Index Terms

TRT Terms: Air pollution; Diseases and medical conditions; Environmental impacts; Highways; Liver; Particulates; Residential location
Subject Areas: Environment; Highways; Planning and Forecasting; Safety and Human Factors;

Filing Info

Accession Number: 01655269
Record Type: Publication
Files: TRIS
Created Date: Dec 27 2017 10:29AM