Antidepressants and Driving in Older Adults: A Systematic Review

The potential consequences of antidepressant use on driving skills in an aging population are becoming a pressing issue, with an increasing number of older drivers who are prescribed antidepressants. A systematic review targeting articles specifically pertaining to antidepressants and driving in a population or subgroup of older adults (= 55 years of age) was conducted by the authors using MEDLINE. Two-hundred-sixty-seven references were yielded by the search, nine of which pertained to the effects of antidepressants on driving in older adults. It was found by this single experimental study that while nefazodone did not have detrimental effects on highway driving, imipramine did. A significant increased risk of involvement in a collision associated with antidepressant use was reported in seven of eight population-based studies. The epidemiological designs cannot exclude the possibility that the underlying illness, generally major depression, is the culprit, although the studies indicated a negative effect of antidepressants on driving.


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  • Accession Number: 01607010
  • Record Type: Publication
  • Files: TRIS
  • Created Date: Jun 17 2016 1:35PM