EFFECTS OF ISONIAZID ON PSYCHOMOTOR SKILLS RELATED TO DRIVING

The effects of single oral dose of 751 mg INII, alone or in combination with 0.5 Gm/kg of alcohol, on psychomotor skills related to driving were investigated. Volunteer cadets (100) were tested with a battery of a choice reaction test, two coordination tests, and an attention test. Further, 50 drivers from motorized troops drove a simulator for 40 minutes. the experiments were double blind. Both INII and alcohol slightly elevated the subjective feeling of performance. At 30 minutes after the ingestion of the drugs, both INII and alcohol shortened reaction time, and INH also improved coordination at 90 and 150 minutes after drug intake. Both alcohol and INH impaired attention. No major interaction was observed between INH and alcohol in psychomtor tests. In simulated driving, INH antagonized the deleterious effect of alcohol on attention. The numbers of collisions at emergency were slightly increased after either drug. The numbers of drivers driving off the road were increased after alcohol and INH given together. After this combination, the small movements of the steering wheel characteristic of drunken drivers were significantly increased. Administration of INH, 10 mg/kg might cause some extra risks for driving in the very beginning of the treatment and in combination with alcohol. /Author/

  • Supplemental Notes:
    • The address for correspondence is: Dr. M. Linnoila, Department of Pharmacology, Siltavuorenpenger 10, Helsinki 17, SF-00170, Finland.
  • Authors:
    • LINNOILA, M
    • MATTILA, M J
  • Publication Date: 1973-8

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Filing Info

  • Accession Number: 00261807
  • Record Type: Publication
  • Source Agency: National Safety Council Safety Research Info Serv
  • Files: TRIS
  • Created Date: Oct 22 1974 12:00AM