Narcolepsy (with and without Cataplexy) and Commercial Motor Vehicle Driver Safety

This evidence report contains four major sections: 1) Background, 2) Crash Statistics, Sleep-related Crash Data, and Relevant Regulations, 3) Methods, and 4) Evidence Synthesis. These major sections are supplemented by extensive use of appendices. The Background section summarizes basic information on the condition of narcolepsy, with and without cataplexy. In the section titled Crash Statistics, Sleep-related Crash Data, and Relevant Regulations, the authors provide information pertaining to current regulatory standards and guidelines from the Federal Motor Carrier Safety Administration (FMCSA) and three other government transportation safety agencies; the Federal Aviation Administration (FAA), the Federal Railroads Administration (FRA), and the Maritime Administration (MARAD). In addition, the authors summarize equivalent information from other countries that are generally considered to have well-developed medical fitness programs. In the Methods section, the authors detail how they identified and analyzed information for this report. The section covers the key questions addressed, details of literature searching, criteria for including studies in the analyses, evaluation of study quality, assessment of the strength of the evidence base for each question, and methods for abstracting and synthesis of clinical study results. The Evidence Synthesis section of this report is organized by key question. For each question, the authors report on the quality and quantity of the studies that provided relevant evidence. The authors then summarize available data extracted from included studies either qualitatively or, when the data permit, qualitatively and quantitatively (using meta-analysis). Each section in the Evidence Synthesis section closes with conclusions that are based on the authors' assessment of the available evidence.

  • Record URL:
  • Corporate Authors:

    MANILA Consulting Group, Incorporated

    1420 Beverly Road, Suite 220
    McLean, VA  United States  22101

    Federal Motor Carrier Safety Administration

    1200 New Jersey Avenue, SE
    Washington, DC  United States  20590
  • Authors:
    • Bieber-Tregear, Michelle
    • Williams, Jessica Roberts
    • Tregear, Stephen
  • Publication Date: 2009-10-6


  • English

Media Info

  • Media Type: Digital/other
  • Features: Appendices; Bibliography; Figures; Tables;
  • Pagination: 177p

Subject/Index Terms

Filing Info

  • Accession Number: 01575244
  • Record Type: Publication
  • Contract Numbers: GS-10F-0177N/DTMC75-06- F-00039
  • Created Date: Aug 25 2015 9:51AM