EFFECTS OF DIAZEPAM, CHLORDIAZEPOXIDE, THIORIDAZINE, HALOPERIDOLE, FLUPENTHIXOLE AND ALCOHOL ON PSYCHOMOTOR

The effects of diazepam, chlordiazepoxide, thioridazine, haloperidole and flupenthixole, alone or in combination with alcohol, on psychomotor skills related to driving were investigated in 400 healthy volunteers. A choice reaction test, two co-ordination tests and an attention test were employed. Benzodiazepines alone relaxed the subjects and they had additive effects in combination with alcohol on reaction and co-ordination. Thioridazine had a more deleterious effect on attention than the benzodiazepines, and it had slight additive effects with alcohol on co-ordination. Haloperidole and flupenthixole scarcely altered reactive or co-ordinative skills, and they did not interact with alcohol. Their effects on attention were deleterious. The strong interaction of benzodiazepines with alcohol should be considered in medical practice, particulary in treating neurotic patients, who often use drugs in combination with alcohol.

  • Corporate Authors:

    Finnish Medical Society Duodecim

    Runeberginkatu 47 A
    00260 Helsinki 26,   Finland 
  • Authors:
    • LINNOILA, M
  • Publication Date: 1973-3

Media Info

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Filing Info

  • Accession Number: 00260746
  • Record Type: Publication
  • Source Agency: Highway Safety Research Institute
  • Files: TRIS
  • Created Date: Nov 6 1974 12:00AM