Unexplained Hypoxia in an In-Flight Emergency

Aircrew are prohibited from using nutritional supplements and over-the-counter medications while flying unless approved by an aeromedical professional. There is a lack of safety data regarding most nutritional supplements, and the perception that these supplements are harmless means that use is common among aircrew, despite the prohibition. This case report presents details of an aircrew member who experienced unexplained hypoxia during an in-flight emergency. A thorough medical investigation took place, and the patient eventually admitted to the use of C4 Extreme, a pre-workout supplement. Exposure to simulated altitude both on and off the supplement indicated that the patient had improved tolerance to a hypoxic environment after discontinuation of the supplement. Data were not conclusive, but suggest that the use of C4 Extreme could be implicated in this case.


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  • Accession Number: 01529270
  • Record Type: Publication
  • Files: TRIS
  • Created Date: Jun 5 2014 4:35PM