Outdoor air pollution and asthma

Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this series paper, the authors discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. The authors focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodeling, and increased risk of sensitization. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. The authors also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma. This is the first in a series of two papers about asthma.

Language

  • English

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Filing Info

  • Accession Number: 01526919
  • Record Type: Publication
  • Files: TRIS
  • Created Date: May 7 2014 1:25PM