Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy

This paper focuses on fitness to drive impairment of cirrhotic patients with minimal hepatic encephalopathy (MHE). Specifically, it examines the neurological deficits contributing to driving impairment and seeks to identify psychometric tests or biochemical parameters that are good indicators of driving impairment. A driving simulator (SIMUVEG) and Driver Test was used to assess driving performance in cirrhotic patients with and without MHE. Various neurological functions were evaluated using psychometric tests and blood ammonia and nitric-oxide-cGMP metabolism-related parameters were measured. The results found that patients with MHE show psychomotor slowing, longer reaction times as well as impaired visuospatial coordination and concentrated attention. Serum 3-nitrotyrosine was also found to be associated with driving impairment.

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  • Authors:
    • Felipo, Vicente
    • Urios, Amparo
    • Valero, Pedro
    • Sánchez, Mar
    • Serra, Miguel A
    • Pareja, Ignacio
    • Rodríguez, Felicidad
    • Gimenez-Garzó, Carla
    • Sanmartín, Jaime
    • Montoliu, Carmina
  • Publication Date: 2013-11


  • English

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  • Accession Number: 01498905
  • Record Type: Publication
  • Files: TRIS
  • Created Date: Nov 21 2013 9:12AM