Evaluation of the on-site Draeger DrugTest 5000 in occasional and chronic frequent smokers following controlled cannabis smoking

Cannabis is the most commonly reported illicit drug in drugged driving cases. Achieving accurate oral fluid (OF) cannabinoid on-site results is challenging and essential. Device performance and OF cannabinoid detection windows 30h post-smoking were evaluated in occasional and frequent cannabis smokers. 10 occasional and 14 frequent smokers (18-45 years) provided written informed consent for this Institutional Review Board-approved study, and smoked ad libitum one 6.8 per cent THC cannabis cigarette. OF was collected with the DrugTest 5000 test cassette and Oral-Eze collector (Quest Diagnostics) before and frequently up to 30h post-dose. Sensitivity was 6-11 per cent higher in chronic frequent as compared to occasional cannabis smokers due to longer detection windows and higher true positive rates. Median (range) last detection times with the DrugTest 5000 were 12h and 21h for occasional and frequent smokers, respectively. Three frequent smokers were still positive at 30h, but had up to 5 negative specimens prior to 30h. Sensitivity of the DrugTest 5000 5 ng/mL cutoff was lower for occasional as compared to chronic frequent smokers over the extended 30h monitoring window with the 2 and 1 ng/mL confirmation cutoffs; however, these authentic data after controlled smoking document the best performance to date for on-site cannabinoid tests. Sensitivity within 6 and 8h time frames, representing recent smoking, were 85.6 and 84.7 per cent; and 84.0 and 82.5 per cent at the proposed SAMHSA and DRUID confirmation cutoffs, respectively.

• Record URL:
  http://www.icadtsinternational.com/documents/?category=20th_T2013_Brisbane
• Authors:
  • Huestis, M A
  • Milman, G
  • Mendu, D
  • Lee, D
  • Barnes, A J
  • Schwope, D M
  • Gorelick, D A
  • Desrosiers, N A
• Conference:
  • International Conference on Alcohol, Drugs and Traffic Safety (T2013), 20th, 2013, Brisbane, Queensland, Australia
• Publication Date: 2013-8

Language

• English

Media Info

• Pagination: 362-7
• Monograph Title: 20th International Conference on Alcohol, Drugs and Traffic Safety Conference Proceedings, 25-28 August 2013, Brisbane Convention and Exhibition Centre, Brisbane, Australia

Subject/Index Terms

• TRT Terms: Accuracy; Drivers; Drug effects; Drugged drivers; Drugs; Errors; Medical examinations and tests; Reliability; Saliva; Tests; Time
• ATRI Terms: Accuracy; Drug driving; Drug effects; Reliability; Saliva test; Time
• ITRD Terms: 8122: USA
• Subject Areas: Safety and Human Factors; I83: Accidents and the Human Factor;

Filing Info

• Accession Number: 01495685
• Record Type: Publication
• Source Agency: ARRB
• Files: ITRD, ATRI
• Created Date: Oct 17 2013 10:12AM