Higher levels of hair EtG in patients with decreased kidney function

Hair levels of ethyl glucuronide (EtG) are often used in cases where driving qualifications are evaluated, as hair EtG levels are able to differentiate alcohol abstention from social or heavy drinking. Patients with decreased kidney function have delayed excretion of EtG, and increased incorporation into hair could be suspected. The aim of this study was to compare hair EtG levels in patients with decreased kidney function to those seen in healthy volunteers. 19 renal disease patients were included. The levels of EtG in hair were adjusted to estimated daily intake of ethanol (EDI) and compared to 21 previously published healthy individuals. The preliminary results was published earlier this year, but in this publication for the ICADTS-conference 2013, we will in addition present data from a larger material from which data collection is currently taking place. The levels of hair EtG in the 19 patients ranged between less than the limit of detection (LOD) and 134 pg/mg, and the EDI ranged between 0.1 and 28 g. The levels of EtG in hair were significantly higher in the patients with decreased kidney function compared to healthy volunteers. These preliminary results indicate that hair levels of EtG in a population of patients with decreased kidney function should be interpreted with caution. This should be remembered if this analysis is used to assess suitability to hold a driving license.

Language

  • English

Media Info

  • Pagination: 272-6
  • Monograph Title: 20th International Conference on Alcohol, Drugs and Traffic Safety Conference Proceedings, 25-28 August 2013, Brisbane Convention and Exhibition Centre, Brisbane, Australia

Subject/Index Terms

Filing Info

  • Accession Number: 01495671
  • Record Type: Publication
  • Source Agency: ARRB
  • Files: ITRD, ATRI
  • Created Date: Oct 17 2013 10:12AM