Anti-depressants and road safety: a literature review and commentary

This report presents a systematic review of driving performance and accident risk in relation to antidepressant drugs based on relevant summary criteria for literature published after 1989. The evidence suggests that there is reliable evidence that older types of antidepressant drug such as TCA do affect psychomotor functions in a manner that can impair driving performance and increase accident risk. However, whereas there is some evidence that newer drugs such as SSRIs can also affect some functions, there is less evidence that driving performance is as impaired and very little research that considers the accident risk of these drugs. The recent observation that effects of SSRIs on performance are observed in repeated dose studies is cause for concern and highlights the need for independent research to corroborate the effects observed. At present, those studies suggest that the effect of RIMAs on psychomotor performance is also less than for TCAs. On the basis of this review, it is concluded that more research is required to investigate the effects of new generation antidepressant drugs on driving performance and accident risk. In this regard, the report concludes with recommendations for future research.


  • English

Media Info

  • Pagination: 56p
  • Serial:
    • Issue Number: 18

Subject/Index Terms

Filing Info

  • Accession Number: 01388781
  • Record Type: Publication
  • Source Agency: ARRB
  • Files: ATRI
  • Created Date: Aug 23 2012 1:17AM