INHALATION TOXICOLOGY: X. TIMES TO INCAPACITATION FOR RATS EXPOSED CONTINUOUSLY TO CARBON MONOXIDE, ACROLEIN, AND TO CARBON MONOXIDE-ACROLEIN MIXTURES

Laboratory rats were exposed to experimental atmospheres of (a) carbon monoxide (CO) in air, (b) acrolein in air, and (c) to mixtures of CO and acrolein in air. The toxic potency of each of the three types of environments was evaluated toxicokinetically by measurement of time-to-incapacitation (ti) as a function of toxic gas concentrations. Regression equations were derived that related the observed ti's to the concentrations of individual gases. Comparison of the combined-gas-exposure data with results obtained from the individual gas exposures indicated that there was no evidence of synergistic action, i.e., that the effect of the combination was never greater than that predicted by the sum of the two individual gas effects. Evidence did exist for an inhibitory or antagonistic effect of undefined mechanism when acrolein was present in the mixture at concentrations of lesser toxic potency than that of CO. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and acrolein concentrations within the ranges utilized in the experimental exposures.

• Record URL:
  http://www.faa.gov/data_research/research/med_humanfacs/oamtechreports/1990s/media/AM90-15.pdf
• 
• Corporate Authors:

  Federal Aviation Administration

  Office of Aerospace Medicine, 800 Independence Avenue, SW
  Washington, DC  United States  20591
• Authors:
  • Crane, C R
  • Sanders, D C
  • Endecott, B R
• Publication Date: 1990-12

Language

• English

Media Info

• Features: Figures; References; Tables;
• Pagination: 25 p.

Subject/Index Terms

• TRT Terms: Aviation safety; Carbon monoxide; Laboratory animals; Laboratory studies; Lungs; Poisonous gases; Regression analysis; Toxicity; Toxicology
• Uncontrolled Terms: Acrolein; Time-to-incapacitation
• Subject Areas: Aviation; Data and Information Technology; Safety and Human Factors;

Filing Info

• Accession Number: 00942413
• Record Type: Publication
• Report/Paper Numbers: DOT/FAA/AM-90/15
• Files: TRIS, USDOT
• Created Date: May 16 2003 12:00AM