A LITERATURE SURVEY OF GENETIC AND CARCINOGENIC EFFECTS OF SOME COMPONENTS IN PETROL

LITTERATURSAMMANSTAELINING ROERANDE GENETISKA OCH CARCINOGENA EFFEKTER AV NAAGRA KOMPONENTER I MOTORBENSIN

The first part of this survey deals with effects of 1,2-dibromoethane, 1,2-dichloroethane and alkyllead. All results unequivocally show that these substances induce genetic damage-point mutations. Recent investigations also show that the mutagenic effect of these compounds can be enhanced through metabolism in the liver, specifically through a conjugation to glutathione. Dibromoethane induced carcinomas in animal tests and dichloroethane is under testing by the National Cancer Institute in the USA. It seems very likely, according to mutation and metabolism data that 1,2-dichloroethane also is carcinogenic. The alkyllead compounds have only been tested to a limited extent. It is evident, however, that alkyllead compounds can interfere with cell division and give rise to non-disjunction. The second part deals with effects of methanol, n-propanol and iso-butanol. In most articles where genetic effects have been reported also toxic effects were apparent because relatively high doses were used. It therefore seems likely that the biological effects involving risks are predominantly the acute-toxic or indirect ones. It is possible, however, that alkyl nitrites are being formed during combustion. The risks of using alcohols as gasoline additives could be dependent on alkyl nitrites rather than the direct effects of the alcohols. /TRRL/

• Corporate Authors:

  National Swedish Environmental Protection Board

  Smedesvagen 5, Fack
  S-171 20 Solna,   Sweden 
• Authors:
  • RANNUG, U
• Publication Date: 1977

Language

• Swedish

Media Info

• Features: References;
• Pagination: 31 p.

Subject/Index Terms

• TRT Terms: Alcohols; Diseases and medical conditions; Exhaust gases; Gasoline; Genetics; Halides; Health; Hydrocarbons; Lead (Metal); Liver; Nitrites; Toxicity
• ITRD Terms: 7347: Alcohol; 2442: Emission; 7314: Halide; 2144: Health; 7367: Hydrocarbon; 2134: Illness; 7138: Lead (metal); 2154: Medical aspects; 2142: Toxicity; 2043: Viscera
• Subject Areas: Highways; Safety and Human Factors;

Filing Info

• Accession Number: 00178628
• Record Type: Publication
• Source Agency: Transport and Road Research Laboratory (TRRL)
• Report/Paper Numbers: SNV PM 908 Monograph
• Files: ITRD, TRIS
• Created Date: Sep 27 1978 12:00AM