THE OXIDATION CATALYTIC CONVERTER REDUCES THE INHIBITORY ACTIVITY OF SOLUBLE ORGANIC FRACTIONS OF DIESEL PARTICLES ON INTERCELLULAR COMMUNICATION

The genotoxicity of diesel particles has been widely documented, and their tumor promoting effect has been reported recently using the gap junction intercellular communication (GJIC) assay. In the study, the ability of soluble organic fractions (SOF) of diesel particles emitted from cars equipped (WC) or not (WoutC) with the oxidation catalytic converter (OCC) and of particle SOF from an outdoor high polluted place (OHPP) to inhibit GJIC has been evaluated with two cell lines: a rat liver epithelial cell line (REL cells) and a rat pulmonary alveolar type II cell line (3T cells). With both cell lines, the results demonstrate that GJIC is strongly inhibited by WoutC, whereas it is much less reduced by WC ones: for REL cells, the activity of WC particles is 1/4 off the one of WoutC. Also, the authors show that the inhibition induced by WoutC is associated with a change in the GJ protein localization. Their results clearly show the effectiveness of the OCC technology in reducing both the tumor promoting activity and the genotoxicity of diesel particle SOF. (A)

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• Corporate Authors:

  American Chemical Society

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• Authors:
  • VANRULLEN, I
  • CHAUMONTET, C
  • PORNET, P
  • VERAN, F
  • MARTEL, P
• Publication Date: 2000-4-1

Language

• English

Media Info

• Features: References;
• Pagination: p. 1352-8
• Serial:
  • Environmental Science & Technology
  • Volume: 34
  • Issue Number: 7
  • Publisher: American Chemical Society
  • ISSN: 0013-936X
  • EISSN: 1520-5851
  • Serial URL: http://pubs.acs.org/journal/esthag

Subject/Index Terms

• TRT Terms: Catalytic converters; Data communications; Diesel engines; Fuels; Particles; Telecommunications; Telephone
• ITRD Terms: 1394: Catalytic converter; 8652: Data transmission (telecom); 1314: Diesel engine; 3850: Fuel; 4511: Particle; 9117: Telecommunication; 390: Telephone
• Subject Areas: Energy;

Filing Info

• Accession Number: 00793594
• Record Type: Publication
• Source Agency: Transport Research Laboratory
• Files: ITRD
• Created Date: Jun 15 2000 12:00AM