INHALATION TOXICOLOGY: XI. THE EFFECT OF ELEVATED TEMPERATURE ON CARBON MONOXIDE TOXICITY
Laboratory rats were exposed to: (a) experimental concentrations of carbon monoxide in air at ambient temperature, (b) elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurement of time-to-incapacitation (ti) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated that incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and temperature within the ranges utilized in the experimental exposures.
- Record URL:
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Corporate Authors:
Federal Aviation Administration
Office of Aerospace Medicine, 800 Independence Avenue, SW
Washington, DC United States 20591 -
Authors:
- Sanders, D C
- Endecott, B R
- Publication Date: 1990-12
Language
- English
Media Info
- Features: Figures; References; Tables;
- Pagination: 18 p.
Subject/Index Terms
- TRT Terms: Carbon monoxide; Heat; High temperature; Laboratory animals; Laboratory studies; Lungs; Poisonous gases; Toxicity; Toxicology
- Uncontrolled Terms: Time-to-incapcitation
- Subject Areas: Aviation; Safety and Human Factors;
Filing Info
- Accession Number: 00942414
- Record Type: Publication
- Report/Paper Numbers: DOT/FAA/AM-90/16
- Files: TRIS, USDOT
- Created Date: May 16 2003 12:00AM