SCREENING OF ANTIHISTAMINE AGENTS (DIPHENHYDRAMINE) WITH BLOOD AND URINE SAMPLES BY REMEDI-HS SYSTEM

Diphenhydramine (Dip) is one of the antihistamine agents (Anti-His) which are often compounded in cold remedies in Japan. Because of its sedative effects, it is advisable for drivers not to take it. However, as cold remedies can be obtained without a doctor's prescription, Dip is frequently taken by all age groups in Japan. Urine specimens of cadavers from traffic accidents have been found to be Anti-His positive. A noninvasive screening for Anti-His as well as alcohol on drivers seems therefore necessary in order to examine whether etiologically Anti-His was directly involved in the occurrence of traffic accidents. Urine samples were collected from 5 male volunteers at 0, 1, 2, 3, 6, 9, 24, 36 and 50 hours after Dip intake (a single 30 or 60mg oral dose), and 1 ml of each urine sample was used for the analysis by REMEDi-HS. Dip and its 3 different kinds of metabolites, which reached their maximum concentrations at 3 hours, were detected. Maximum concentration of Dip ranged from 0.53 to 4.15 micrograms per ml (mean value = 1.93 micrograms per ml. SD=1.53). At 1 hour only one specific metabolite was detected. The results show that REMEDi-HS is useful for the Dip screening in human urine samples and that the metabolite is an early index suitable for revealing Dip intake. (a) For the record of the covering entry of this conference, please see IRRD abstract no 868581.

• Record URL:
  http://www.icadtsinternational.com/documents/?category=13th_T1995_Adelaide
• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/isbn/0908204213
• Corporate Authors:

  NH&MRC ROAD ACCIDENT RESEARCH UNIT

  UNIVERSITY OF ADELAIDE
  ADELAIDE, SOUTH AUSTRALIA  Australia  5005
• Authors:
  • OHTSUJI, M
  • OHSHIMA, T
  • TAKAYASU, T
  • NISHIGAMI, J
  • KONDO, T
  • Lin, Z
  • MINAMINO, T
• Conference:
  • ALCOHOL, DRUGS AND TRAFFIC SAFETY - T'95, 13 AUGUST - 18 AUGUST 1995; PROCEEDINGS OF THE 13TH INTERNATIONAL CONFERENCE ON ALCOHOL, DRUGS AND TRAFFIC SAFETY, ADELAIDE
• Publication Date: 1995

Language

• English

Media Info

• Features: References;
• Pagination: p. 321-6
• Serial:
  • Volume: 1

Subject/Index Terms

• TRT Terms: Conferences; Detection and identification; Detectors; Drivers; Drugs; Tests
• Geographic Terms: Japan
• ITRD Terms: 8525: Conference; 9115: Detection; 1772: Driver; 2242: Drugs; 8053: Japan; 6255: Test
• Subject Areas: Data and Information Technology; Safety and Human Factors;

Filing Info

• Accession Number: 00731273
• Record Type: Publication
• Source Agency: ARRB
• ISBN: 0-908204-21-3
• Files: ITRD, ATRI
• Created Date: Feb 27 1997 12:00AM