NONINVASIVE ESTIMATION OF BLOOD ALCOHOL CONCENTRATIONS. ETHANOL VAPOR ABOVE THE EYE

A novel approach to the in vivo, noninvasive determination of alcohol in the body of animals is described. The conentration of ethanol in vapor above the lacrimal fluid in the eye was analyzed in situ by the use of fast gas sensor method developed for biological liquids. After an oral dose of 1 g/kg to 11 animals, eye vapor measurements and blood samples were obtained over 4 hour. The correlation of 61 blood ethanol concentrations obtained by the two methods yielded a correlation coefficient of 0.92 and a slope of 0.99. The metabolic rates of ethanol determined by gas chromatographic analysis of blood and by ethanol eye vapor analysis are virtually identical. The data suggest that ethanol eye vapor analysis may be an attractive, noninvasive method for determination of ethanol in animals.

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/issn/01456008
• Corporate Authors:

  Marcel Dekker, Incorporated

  270 Madison Avenue
  New York, NY  United States  10016
• Authors:
  • Giles, H G
  • Sandrin, S
  • Saldivia, V
  • Israel, Y
• Publication Date: 1988

Media Info

• Pagination: p. 255-258
• Serial:
  • Alcoholism: Clinical and Experimental Research
  • Volume: 12
  • Issue Number: 2
  • Publisher: Blackwell Publishing
  • ISSN: 0145-6008
  • EISSN: 1530-0277
  • Serial URL: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1530-0277

Subject/Index Terms

• TRT Terms: Alcoholic beverages; Blood alcohol levels; Drunk drivers; Drunk driving; Eye; Testing
• Subject Areas: Highways; Safety and Human Factors; I83: Accidents and the Human Factor;

Filing Info

• Accession Number: 00489420
• Record Type: Publication
• Files: TRIS
• Created Date: Nov 30 1989 12:00AM