EFFECTS OF TWO ANTIHISTAMINE DRUGS ON ACTUAL DRIVING PERFORMANCE

A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures of mood and arousal, and despite an awareness that their driving was impaired while they were taking this agent subjects could not correct their performance. This study suggests that drivers who need antihistamine drugs should avoid those that act centrally. (Author/TRRL)

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/issn/00071447
• Corporate Authors:

  British Medical Association

  BMA House, Tavistock Square
  London WC1H 9JR,   United Kingdom 
• Authors:
  • Setts, T
  • Markman, D
  • Debenham, S
  • Mortiboy, D
  • McKevitt, T
• Publication Date: 1984-1

Media Info

• Features: References; Tables;
• Pagination: p. 281-282
• Serial:
  • BMJ
  • Volume: 288
  • Issue Number: 6413
  • Publisher: British Medical Association
  • ISSN: 0959-8138
  • Serial URL: http://www.bmj.com/

Subject/Index Terms

• TRT Terms: Antihistamines; Aptitude; Behavior; Driver performance; Drivers; Driving; Drugs; Personnel performance
• ITRD Terms: 1772: Driver; 2226: Driving aptitude; 2242: Drugs
• Subject Areas: Highways; Safety and Human Factors; I83: Accidents and the Human Factor;

Filing Info

• Accession Number: 00385500
• Record Type: Publication
• Source Agency: Transport Research Laboratory
• Files: ITRD, TRIS
• Created Date: Jun 28 1984 12:00AM