OBJECTIVE EFFECTS OF AN INTERMEDIATE TRANQUILIZER ON DRIVING PERFORMANCE

MESORIDAZIN WAS TESTED ON A TOTAL OF 85 TRIAL SUBJECTS AT DIFFERENT LEVELS AND FOR DIFFERENT PERIODS OF ADMINISTRATION FROM THE POINT OF VIEW OF DECREASED ABILITY TO OPERATE A MOTOR VEHICLE. WITH SHORT TERM AND HIGH DOSAGE LEVELS A SIGNIFICANT DECREASING EFFECT ON THE STRESSABILITY OF THE REACTIONS AND A TENDENCY TO AFFECT SENSORY AND MOTOR COORDINATION WAS SHOWN. WITH MORE PROLONGED ADMINISTRATION AND LOWER DOSAGE LEVELS A DECREASE OF THE REACTION SPEED TO SINGLE OPTICAL SIGNALS WAS OBSERVED, BUT THIS HAS ONLY A SLIGHT BEARING ON THE ABILITY TO DRIVE. THE RESULTS SEEM TO INDICATE THAT MESORIDAZIN, GIVEN IN THE RECOMMENDED DOSAGE OF 3 TIMES DAILY 5 MG, DOES NOT RESTRICT DRIVING ABILITY. HOWEVER, HIGHER DOSES ARE CONTRAINDICATED FOR OPERATORS OF MOTOR VEHICLES. ADMINISTRATION OF THE DRUG FOR 7 DAYS DID NOT SHOW SIGNIFICANT CUMULATIVE EFFECTS. /SRIS/

• Supplemental Notes:
  • Vol 109, No 5, PP 253-258
• Corporate Authors:

  Munchener Medezinische Wochenschrift

  ,    
• Authors:
  • BIEHL, B
  • Seydel, U
• Publication Date: 1967

Subject/Index Terms

• TRT Terms: Driver performance; Drivers; Personnel performance; Reaction time; Tranquilizers
• Subject Areas: Highways; Safety and Human Factors;

Filing Info

• Accession Number: 00222929
• Record Type: Publication
• Source Agency: Nat Safety Council Safety Res Info Serv
• Files: TRIS
• Created Date: Sep 8 1994 12:00AM