Simulation of Human Head Response to Impact Loading Using Newly Developed Biofidelic Material Models for Brain Tissue

This research sought to develop a biofidelic material model for brain tissue by accounting for the underlying microstructure of the material. Based on the microstructure observed at the neuron level, a mesoscale model was developed which included neurons, glial cells and Cerebro-Spinal Fluid (CSF). A semi-analytical model was first developed using a simplified geometry accounting for separate fiber and matrix (fluid) behavior of the medium. A second computational model was constructed by developing a representative volume element of brain tissue that includes the neurons, glial cells and CSF. Diffusion Tensor Imaging was also utilized to capture anisotropy and directional dependence of the tissue on the continuum scale. Using these models, computational simulations were performed to predict the mechanical response of the brain tissue when subjected to a non-penetrating, impact load.

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/isbn/9780615545103
• Authors:
  • Littlefield, David L
  • Kulathu, Sandeep
• Conference:
  • 55th Stapp Car Crash Conference
  • Location: Dearborn Michigan, United States
  • Date: 2011-11-7 to 2011-11-9
• Publication Date: 2011-11

Language

• English

Media Info

• Media Type: Print
• Features: Appendices; Figures; References; Tables;
• Pagination: pp 75-89
• Serial:
  • Stapp Car Crash Journal
  • Volume: 55
  • Publisher: Society of Automotive Engineers (SAE)
  • ISSN: 1532-8546
  • Serial URL: http://www.stapp.org/pubs.shtml

Subject/Index Terms

• TRT Terms: Brain; Crash injury research; Crash tests; Head; Mathematical models; Simulation
• Subject Areas: Highways; Safety and Human Factors; I84: Personal Injuries;

Filing Info

• Accession Number: 01372267
• Record Type: Publication
• ISBN: 9780615545103
• Report/Paper Numbers: 2011-04
• Files: TRIS
• Created Date: Jun 8 2012 12:33PM