THE COMBINED EFFECT OF ALCOHOL AND AMITRIPTYLINE ON SKILLS SIMILAR TO MOTOR-CAR DRIVING

IN A DOUBLE-BLIND STUDY, 12 NORMAL SUBJECTS WERE GIVEN AMITRIPTYLINE, IN A DOSAGE OF 50 MG EVERY 12 HOURS, FOR FIVE DAYS AND WERE TESTED BY MEANS OF A MOTOR SKILL BATTERY WITH AND WITHOUT ALCOHOL ADMINISTRATION. COMPARISONS WITH AN EQUALLY CONSTITUTED CONTROL GROUP SHOWED THAT SOME DECREMENTS IN PERFORMANCE WERE DUE TO ALCOHOL CONSUMPTION. AMITRIPTYLINE ADMINISTRATION DID NOT SIGNIFICANTLY AFFECT TEST PERFORMANCE, NOR WAS ANY SIGNIFICANT INTERACTION EFFECT NOTED. THE IMPORTANCE OF TESTING FOR INTERACTION BETWEEN THE COMMONLY PRESCRIBED PSYCHOTROPIC AGENTS AND ALCOHOL IS DISCUSSED SINCE POTENTIATION OF ALCOHOL EFFECTS MAY AT TIMES CONTRIBUTE TO TRAFFIC ACCIDENTS AND THE HAZARDS OF DRUG OVERDOSAGE. /AUTHOR/

• Availability:
  • Find a library where document is available. Order URL: http://worldcat.org/issn/0025729X
• Supplemental Notes:
  • Vol 2, pp 946-949, 1 TAB, 18 REF
• Authors:
  • Patman, J
  • Landauer, A A
  • Milner, G
• Publication Date: 1969-11-8

Media Info

• Serial:
  • Medical Journal of Australia
  • Publisher: Australasian Medical Publishing Company
  • ISSN: 0025-729X
  • Serial URL: https://onlinelibrary.wiley.com/journal/13265377

Subject/Index Terms

• TRT Terms: Alcohols; Crash causes; Driving; Drugs; Motor skills; Performance tests; Psychotropic agents; Traffic crashes
• Uncontrolled Terms: Interaction
• Old TRIS Terms: Amitriptyline
• Subject Areas: Highways; Safety and Human Factors;

Filing Info

• Accession Number: 00223328
• Record Type: Publication
• Source Agency: Nat Safety Council Safety Res Info Serv
• Files: TRIS
• Created Date: Jan 18 1971 12:00AM